CompARE is a web-platform inspired to provide help on issues relating to trials with composite endpoints. CompARE may be used as a tool for calculating the elements needed in the planning phase of clinical trials involving composite endpoints. With its user-friendly interface, CompARE allows to input the main parameters included in the trial -such as the treatment effect on the components of the composite endpoint, and its frequencies of occurrence- and helps provide power and sample size calculations among others.
CompARE is split into two apps for time-to-event and
binary endpoints, respectively. They are implemented with the Shiny R
package.
Time to event app (button) and binary app (button)
Effect size: Studying the treatment effect for the composite endpoint
Sample Size: Computing the number of patients under different scenarios
Endpoint Selection: Identifying the best endpoint combination for the design
Association:Assessing the degree of association between components